Lidocaine HCL is a local anesthetic and IB antiarrhythmic drug. Its anesthetic effect blocks the sodium ions influx through the nerve membranes surrounding the area of its application. This inhibits the pain signal to reach the brain.
As an antiarrhythmic drug, it blocks sodium channels to decrease the heart contraction rate after injecting through nerves. It prevents signals to reach the brain through nerves.
It is included in the list of essential medicines in the World Health Organization’s List. Lidocaine Hydrochloride API price in India is one of the best among all other international manufacturers. Hence, India produces a bulk quantity of Lidocaine HCL for global pharmaceutical companies.
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- Product Type – API
- Chemical Formulae – C14H25ClN2O2
- Molecular Weight – 288.82 g/mol
- Synonyms – Lidocaine hydrochloride 73-78-9 LIDOCAINE HCL Lidothesin Xyloneural
- Documents available – USDMF, EDMF, DMF, USFDA, GMP, ISO, WHO-GMP
- Packaging – Standard Packaging & Labelling as per FDA
- Application – Numbing skin pain or irritation reducing itching, scrapes, minor burns, etc. Prevents irregular heart rhythm
- Dosage – Don’t use it more than 4 times in 24 hours. However, dosage depends on age, weight and reaction. (Take the medicine as per the Doctor’s advice)
- Side Effects – Low blood pressure, swelling, shallow breathing, dizziness, blurred vision, etc.
Mechanism of Action
The main working principle of Lidocaine HCL is to numb the sensation by blocking the pain signal to reach the brain and also abort the pain impulse generation. It’s an amide-type local anesthetic that prohibits ionic influx and stabilizes neuronal membranes.
It directly acts on the internal surface of nerve cell membranes where the sodium ion channel is present. Neutrally uncharged molecules of lidocaine diffuse into axoplasm through neutral sheaths and join hydrogen ions for ionizing. Hence, the cations of lidocaine reversibly bind with the sodium channels and lock them in an open state that ceases nerve depolarization. As a result, the postsynaptic neuron fails to transmit potential action.
Furthermore, its action affects the cardiovascular and central nervous systems. It stimulates CNS and acts on the myocardium to decrease the electrical conduction rate and force of contraction.
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